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Tri-Heart Plus

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Tri-Heart Plus - 51-100 Lbs (Brown) - 1 Dose
$7.99 $6.99
Tri-Heart Plus - 1-25 Lbs (Blue) - 6 Doses
$24.99 $15.99
Tri-Heart Plus - 1-25 Lbs (Blue) - 12 Doses
$42.99 $29.99

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Tri-Heart Plus

Tri-heart plus is a microfilaricide monthly, oral preventative medication used in dogs to prevent parasites.

How it Works
Tri-heart Plus is a combination medicine containing both ivermectin and pyrantel pamoate. Ivermectin interferes with the parasite’s transmition of nerves leading to paralysis and termination of heartworms. Pyrantel Pamoate interferes with the parasite’s transmition of nerves leading to paralysis and termination of hookworms.


Tri-heart Plus is formulated to kill the immature heartworm (Dirofilaria immitis) and is also used to treat/control hookworm (Ancylostoma caninum, A. brasiliense, and Uncinaria stenocephala)  infestations.

The early stages of the heartworm (Dirofilaria immitis) and the hookworm (Ancylostoma caninum, A. brasiliense, and Uncinaria stenocephala) do not permit symptoms in dogs. It is not until the parasites have thrived within the pet will symptoms be noted. The heartworm is transmitted into a dog through the mosquito bite. As the mosquito takes his blood meal, he injects the larvae stage heartworm into the dermal layer of the dog’s body. Once the heartworm has matured into mature larvae he will travel into the blood stream of the dog until he reaches the heart.

After several years definite signs will develop as the parasite reproduces, invading the heart and lungs. A dog will develop a cough due to worms beginning to crowd the lungs. This cough could be very mild or severe. Your pet may also appear to be tired or worn out. You would notice these symptoms quickly in a high spirited pet. Loss of appetite and weight loss are also common signs your pet could be infested with heartworms as well as jaundice and fever. Jaundice, or a yellowing of the mucus membranes, occurs when the liver is failing. These signs are more serious and are reaching the stage of no return.

Hookworms are potentially dangerous to cats, dogs, rodents, and humans. In other words hookworm disease is Zoonotic, meaning a disease of animals that is transmitted to humans.  The hookworm that takes host to canines is called Ancylostoma caninum. This hookworm can penetrate the human skin causing a condition called cutaneous larval migrants, more commonly called creeping eruption or ground itch in lament terms. The life cycle of the hookworms begins like many others, as eggs. These eggs pass through fecal matter of infected mammals and under warm conditions, hatch into larva within approximately one to two days. These larvae thrive in the fecal matter and soil for about a week, where they then proceed to molt two more times.

The hookworm searches for a host at the stage three life cycles. The hookworm will hook onto the skin of a host, penetrating the skin deep. Once inside the host, they are carried through the blood vessels to the heart and then into the lungs. The worms now begin to move quickly, piercing through the pulmonary alveoli, reaching the bronchial tree to the pharynx (lung and throat region) and the host swallows them. The larva then move toward the intestines where they will mature, reproduce, and thrive. A pet infected with hookworms will display severe diarrhea, bloody diarrhea, become weak, develop a poor hair coat, and lose weight.

Only a few years ago the epidemic of heartworm disease was primarily located in the southern parts of the United States. Over the years, heartworm disease has spread all over the world as the migration of mosquitoes (the vector of heartworm filarial) enters into new locations of the world. Pet owners should take heartworm disease as well as hookworm infestations very seriously as pet aliments include; sudden collapse, harsh cough, drowsiness, diarrhea, and sudden death.


Heartworm disease and hookworms affects all dogs and cats around the world. There is only one breed of heart worm; Dirofilaria immitis and two breeds of hookworms; Ancylostoma caninum, A. brasiliense, and Uncinaria stenocephala.


My dog weighs less than 10lbs but the package says give to dogs of 25 pounds. So I administer the whole pill?
a.) Yes. Entire tablet should be taken but break up the pill for easy swallow.

Can Tri-Heart® Plus tablets be given to pregnant females?
a.) Active ingredients; Ivermectin/pyrantel are extremely safe ingredients. These ingredients make the product safe enough to be used in pregnant, lactating females, and puppies 6 weeks old.

I accidentally administered two tablets of the product in one day, will my dog be alright?
a.)Contact your veterinarian immediately if accidental overdose occurs. A good rule of thumb when it comes to treating your pet is to have a calendar of the day you administered product.

My dog is currently taking other medications; will this product interact with medication?
A.)  flea collars, dips, shampoos, anthelmintics (deworming medications), antibiotics, vaccines, and steroid have all been tested as safe to take with this product. On specific medications consult your veterinarian.

I realized my dog has not had his dose from last month administered. Could there be a chance he is no longer protected?
Doses which are more than 30days apart decrees protective effect of product. Consult your veterinarian to have a heartworm test taken to insure your pet is not infected. Administer dose once you remember.

Where could  I purchase Tri-Heart Plus tablets?
a.) This product is available only by veterinary prescription and can be purchased at your local veterinary clinic.

How safe is this product safe?
a.) Tri-heart Plus tablets are FDA approved as safe when administered according to enclosed directions.

One of the tablets within my package of Tri-heart plus came out of its blister pocket. Is this pill still good?
A.) Each tablet is placed within a foil blister pocket to shield said tablet from light and moisture. A pill which has come in contact with either element should not be administered to your pet.

I have a cat which also needs a heartworm preventative; can I use a smaller dose of my dog’s medication?
a.) No. The active ingredients in this product are hazardous to cats and should never be given to felines.  

Is this product still effective to administer after the expiration date?
a.) Tri-Heart® Plus, should never be administered after the expiration date.

Product Cautions
Do not use this product in cats.

Not intended for use in puppies under 6 weeks of age.

Safe for all herding dog breeds, pregnant, and lactating females.

Storage: Store away from sunlight and moisture. Store at room temperature.

Two generic equivalencies of Tri-heart plus are available for use in dogs. Iverhart Plus ad Heartgard Plus contain the same active ingredients as Tri-heart Plus and vary in price. These two generic forms are proven just as effective as Tri-heart when stored appropriately. Generic forms of medications not purchased from a veterinarian may have come into contact with sunlight, decreasing effectiveness.


Product is to be given orally and meant to be chewed.
Medication can be given alongside food.
Break down large pills to ease digestion in small dogs.
Administer pills once a month.

Pet owners; prevent overdose to your pet by scheduling the date to administer. Place a reminder or check off list to ensure dosage on appropriate day.

Administer once monthly for prevention of heartworms and hookworms. Product is to be given according to weight. Pills available for small, medium, and large dogs.

Active ingredients:      
Pyrantel pamoate.    

Recent Customer Reviews:  (2)
Rated 5/5 based on2 customer reviews


OCTOBER 08, 2015

REVIEWER: tri-heart plus - by 



SEPTEMBER 04, 2015

REVIEWER: Good Quality Heartworm Preventative - by 

I have been using this heartworm preventative for years for my dogs and their heartworm tests are always negative. I will continue to use this product for my dogs.