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Selegiline is an inhibitor of the oxidase monomanine which aids in the treatment of canine Cushing’s disease.

Selegiline treats cases of Canine Cognitive Dysfunction Syndrome and Cushing ’s disease.

Cushing’s disease refers to the over production of the hormone cortisol. Cortisol is administered into the body by paired glands in coordinate with the kidneys called the adrenals. Cortisol is a hormone which is released to regulate metabolism, immune responses, and blood increase of sugars. The adrenal glands are regulated by a portion of the brain called the hypothalamus. The hypothalamus delivers messages to the adrenal glands to produce more or less of its producing hormones. The adrenal glands release two hormones in particular along with cortisol; the two hormones normally produced by the adrenal glands, Mineralocorticoids and glucocorticoids, which are located, near the kidneys. Both of these hormones are critical to the healthy functioning of the body, and an abnormal increase or decrease of either of these hormones can lead to serious health problems if not addressed in time.

Cushing’s disease can be life-threatening and there are a variety of symptoms that can be present in many cases. The symptoms of Cushing’s disease include: anorexia, lethargy, weight loss, vomiting, shaking, diarrhea, polyuria (increased urination frequency), depression, polydipsia (increased thirst), dehydration, collapsing episodes, weak pulse, low temperature, hair loss, blood in the feces, and painfulness in the abdomen.

Pet aliments associated with Cushing’s disease include: anorexia, lethargy, weight loss, vomiting, shaking, diarrhea, polyuria (increased urination frequency), depression, polydipsia (increased thirst), dehydration, collapsing episodes, weak pulse, low temperature, hair loss, blood in the feces, and painfulness in the abdomen.


Cushing’s disease occurs for unknown reasons. Veterinary professionals have noted the disease occurs in older aged dogs, some with health problems. No breed of dog is directly connected to this disease as tumors can occur in any pet.


1.What do I do if my pet has adverse effects from product?
        Contact an emergency veterinary center promptly.

2. What side effects could affect my pet while administering this product?
The most common adverse reactions reported are weakness, diarrhea, lethargy, reduced          appetite, and poor hair coat.

3. What signs should I watch for in an overdose?
      Overdose side effects include; collapse, vomiting, and lethargy.

4. How should I protect myself while administering this product to my pet?
Do not handle medication if you are pregnant. Wear protective clothing such as gloves while handling medication. Wash hands with soap and water after administration.

5. What dogs should not take Selegiline?
Those who are pregnant, or those with kidney or liver failure should not take this product.

 6. What happens if I miss a dose?
 Administer the dose as soon as you remember, but never give two doses in one day.

 7. Is this product approved by the FDA?
 Yes, FDA approved to be purchased by a veterinarian.

8. What kind of diagnostic tests will be taken by the veterinarian before use?
The veterinarian will want to know the hormone levels produced by the adrenal glands; therefore, a complete chemistry panel will be conducted. This test requires a small sample of blood from your dog.

9. If Cushing’s disease is in fact a disease, can it ever be cured?
No disease can be 100% cured but it can be managed and increase the life of your pet.

10. Aside from administering Selegiline to aid my pet’s condition, what else will need to be changed in my pet’s lifestyle?
Your pet’s daily routine will not change much. The veterinarian may prescribe a different formula of food specific to the disease.

Product Cautions

Keep product out of the hands of children.

Product is not intended for human use.

Product is to be used with veterinary consent.

Read the entire content of the label before each use.

Products handled improperly can become hazardous to both humans and animals. Read label instructions carefully and follow accordingly.

PET: Not to be used in pregnant or lactating females.

HUMANS: It is injurious to inhale or swallow the contents. Avoid food and water contamination. After use, wash your hands thoroughly with water and soap. Do not handle this medication if you are pregnant.

If Swallowed: Immediately contact a poison control center to be instructed of the situation. Offer water to affected person if said person is in a state of consciousness. Do not encourage the individual to vomit unless instructed by a medical physician.  

If in eyes: If product residue affects the eyes, keep the affected eye open while flushing said eye with water. If individual wears contact lenses, remove the contact and continue flushing eye for five minutes. Continue to cleanse the eye for 20 minutes and contact a medical physician if irritation occurs.

If on skin or clothing: Remove the contaminated clothing immediately and begin washing the skin for 20 minutes. Continue to cleanse the skin with soap and water as you seek advice from a medical professional.

Storage and disposal

Storage: keep product at the same temperature as the room.

Disposal: Dispose un-used or empty containers as directed on the label. Never re-use containers and always recycle or dispose. If you have any questions, contact your local medical waste agency for directions or contact 1-800-CLEANUP for additional information.

The name brand equivalent to this product is Anipryl. Generic products contain the same active ingredients as their brand name comparisons. Brand name comparisons may be more costly than generic brands, but storage regulations are strictly followed. Through proper storage and good handling, generic equivalents work at the same effect rate as name brand products.

How it Works
Unlike other medications used to treat Cushing’s disease, Selegiline reaches straight to the pituitary gland. By suppressing these glands the symptoms of Cushing ’s disease will decrease and leave the pet with less secondary side effects.

To be administered orally. It is unlawful to administer drug in any way other than directed.

Pet    Dosage       
Dogs:     Starting dose: 0.45mg/lbs, one time a day.
After two months: 0.9/lbs.    

Active Ingredient:    Other Ingredients:       
Selegiline hydrochloride, USP 5mg    Citric Acid
Magnesium Stearate
Anhydrous Lactose
 Microcrystalline Cellulose    

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