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Phenylzone Paste Non-steroidal anti-inflammatory for management of musculoskeletal conditions in horses, such as generalized arthritis. Usual dosage is 2-4 grams daily for a 1000 lb. horse. As symptoms regress, dosage may be reduced 25-50%. Each 60 gram tube contains 12 grams of Phenylbutazone.
- PHENYLZONE® PASTE
- Rx
- Schering-Plough
- (phenylbutazone)
- VETERINARY - FOR HORSES ONLY
- NADA #116-087, Approved by FDA.
- DESCRIPTION:
- PHENYLZONE Paste is a synthetic, nonhormonal, anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties.
- Chemically, phenylbutazone is 4-butyl-1,2-diphenyl-3,5-pyrazolidinedione. It is a pyrazolone derivative, entirely unrelated to the steroid hormones, and has the following structural formula:
- INDICATIONS:
- For the relief of inflammatory conditions associated with the musculoskeletal system in horses.
- CONTRAINDICATIONS:
- Use with caution in patients who have a history of drug allergy.
- WARNING:
- Not for use in horses intended for food.
- PRECAUTIONS:
- Stop medication at the first sign of gastrointestinal upset, jaundice, or blood dyscrasia. Authenticated cases of agranulocytosis associated with the drug have occurred in man; fatal reactions, although rare, have been reported in dogs after long-term therapy. To guard against this possibility, conduct routine blood counts at weekly intervals during the early phase of therapy and at intervals of 2 weeks thereafter. Any significant fall in the total white count, relative decrease in granulocytes, or black or tarry stools, should be regarded as a signal for immediate cessation of therapy and institution of the appropriate countermeasures.
- In the treatment of inflammatory conditions associated with infections, specific anti-infective therapy is required.
- ADMINISTRATION AND DOSAGE: Orally - 1 to 2 g of phenylbutazone per 500 lb of body weight, but not to exceed 4 g daily. Use a relatively high dose for the first 48 hours, then reduce gradually to a maintenance dose. Maintain lowest dose capable of producing desired clinical response.
- Guidelines to Successful Therapy:
- 1. Use a relatively high dose for the first 48 hours, then reduce gradually to a maintenance dose. Maintain lowest dose capable of producing desired clinical response.
- 2. The response to PHENYLZONE therapy is prompt, usually occurring within 24 hours. If no significant clinical response is evident after 5 days, reevaluate diagnosis and therapeutic approach.
- 3. When administering PHENYLZONE Paste the oral cavity should be empty. Deposit paste on back of tongue by depressing plunger that has been previously set to deliver the correct dose.
- 4. Many chronic conditions will respond to PHENYLZONE therapy, but discontinuance of treatment may result in recurrence of symptoms.
- STORAGE:
- Store at 15˚-30˚ C (59˚-86˚ F).
- HOW SUPPLIED:
- Syringes containing 6 g and 12 g of phenylbutazone, NDC 0061-5045-01 (6 g), NDC 0061-5040-01 (12 g).
- KEEP OUT OF REACH OF CHILDREN
- CAUTION:
- Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.
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Phenylzone Paste 
