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For: Intramuscular Use In Horses

DESCRIPTION:
Adequan Equine is recommended for the intramuscular treatment of non-infectious degenerative and/or traumatic joint dysfunction and associated lameness of the carpal and hock joints in horses. Adequan requires a prescription from your veterinarian. A syringe is needed, but not included in the package.

INGREDIENT(S):
Each 5 milliliters of Adequan® i.m. contains 500 mg of Polysulfated Glycosaminoglycan and Water for Injection q.s.

CLINICAL PHARMACOLOGY:
Polysulfated Glycosaminoglycan is chemically similar to the glycosaminoglycans in articular cartilage matrix. PSGAG is a potent proteolytic enzyme inhibitor and diminishes or reverses the pathologic processes of traumatic or degenerative joint disease which result in a net loss of cartilage matrix components. PSGAG improves joint function by reducing synovial fluid protein levels and increasing synovial fluid hyaluronic acid concentration in traumatized equine carpal and hock joints.


USES AND INDICATIONS:
Adequan® i.m. is recommended for the intramuscular treatment of non-infectious degenerative and/or traumatic joint dysfunction and associated lameness of the carpal and hock joints in horses.

CONTRAINDICATIONS AND PRECAUTION:
There are no known contraindications to the use of intramuscular Polysulfated Glycosaminoglycan.

ADVERSE EFFECTS AND WARNINGS:
Do not use in horses intended for human consumption. For animal use only. Keep out of the reach of children and other animals.

DOSAGE AND ADMINISTRATION:
The recommended dose of Adequan® i.m. in horses is 500 mg every 4 days for 28 days intramuscularly. The injection site must be thoroughly cleansed prior to injection. Do not mix Adequan® i.m. with other drugs or solvents.

STORAGE:
Store at controlled room temperature up to 25°C (77°F) (See USP). Discard unused portion.

MANUFACTURER: LUITPOLD PHARMACEUTICALS, INC

• ADEQUAN® I.M.
• Rx
• Luitpold
• Brand of Polysulfated Glycosaminoglycan (PSGAG)
• Solution 500 mg/5 mL
• For Intramuscular Use In Horses
• CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
• DESCRIPTION
• Each 5 milliliters of Adequan® i.m. contains 500 mg of Polysulfated Glycosaminoglycan and Water for Injection q.s. Sodium Hydroxide and/or Hydrochloric Acid added when necessary to adjust pH. Sodium Chloride may be added to adjust tonicity.
• PHARMACOLOGY
• Polysulfated Glycosaminoglycan is chemically similar to the glycosaminoglycans in articular cartilage matrix. PSGAG is a potent proteolytic enzyme inhibitor and diminishes or reverses the pathologic rocesses of traumatic or degenerative joint disease which result in a net loss of cartilage matrix components. PSGAG improves joint function by reducing synovial fluid protein levels and increasing synovial fluid hyaluronic acid concentration in traumatized equine carpal and hock joints.
• TOXICITY
• Toxicity studies were conducted in horses. Doses as high as 2,500 mg were administered intramuscularly to 6 horses twice a week for 12 weeks. This dosage is 5 times the recommended dosage and 3 times the recommended therapeutic regimen. Clinical observations revealed no o reness or swelling at the injection site or in the affected joint. No animal had any clinical or laboratory evidence of toxicity.
• INDICATIONS
• Adequan® i.m. is recommended for the intramuscular treatment of non-infectious degenerative and/or traumatic joint dysfunction and associated lameness of the carpal and hock joints in horses.
• CONTRAINDICATIONS
• There are no known contraindications to the use of intramuscular Polysulfated Glycosaminoglycan.
• WARNING
• Not for use in horses intended for food.
• DOSAGE AND ADMINISTRATION
• The recommended dose of Adequan® i.m. in horses is 500 mg every 4 days for 28 days intramuscularly. The injection site must be thoroughly cleansed prior to injection. Do not mix Adequan® i.m. with other drugs or solvents.
• REPRODUCTIVE SAFETY
• Studies have not been conducted to establish safety in breeding horses.
• Dispose of spent needles in accordance with all federal, state and local environmental laws.
• WARNING
• Keep this and all medications out of the reach of children.
• HOW SUPPLIED
• Adequan® i.m. solution, 500 mg/5 mL is available in 5 mL glass vials.
• STORAGE CONDITIONS
• Store at controlled room temperature 18°-25°C (64°-77°F). Discard unused portion.
• Adequan® i.m. (polysulfated glycosaminoglycan) is available only in an injectable, prescription form dispensed by licensed veterinarians. The recommended dose is 500 mg intramuscularly every four days for 28 days.
• Studies have shown that two hours after the first Adequan® i.m. injection, beneficial levels are reached in the joint and therapeutic levels are present for up to 96 hours. To achieve maximum benefit of blocking cartilage destruction and stimulating joint repair processes, make sure your horse receives the entire seven doses recommended by your veterinarian.